Top Guidelines Of phenobarbital sodium tablets
Top Guidelines Of phenobarbital sodium tablets
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ADVERSE REACTIONS The following adverse reactions as well as their incidence ended up compiled from surveillance of Countless hospitalized sufferers.
DESCRIPTION The barbiturates are nonselective central nervous system depressants which might be primarily used as sedative hypnotics and also anticonvulsants in subhypnotic doses. The barbiturates and their sodium salts are subject to manage under the Federal Controlled Substances Act (See “Drug Abuse and Dependence” section). The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital can be obtained as sterile parenteral solutions. Barbiturates are substituted pyrimidine derivatives during which the basic structure frequent to these drugs is barbituric acid, a substance that has no central anxious technique (CNS) activity.
pentobarbital decreases levels of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with powerful CYP3A4 inducers; these drugs cut down exposure to vandetanib by approximately forty%.
pentobarbital will lower the level or effect of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to some reduce in fentanyl plasma concentrations, deficiency of efficacy or, probably, progress of a withdrawal syndrome inside of a patient who may have designed Actual physical dependence to fentanyl.
buprenorphine transdermal and pentobarbital the two boost sedation. Stay clear of or Use Alternate Drug. Restrict use to patients for whom alternative treatment method alternatives are insufficient
Work out caution when administered to sufferers with acute or Continual suffering; could end in paradoxical excitement or vital symptoms can be masked
pentobarbital boosts toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. CYP3A4 inducers may improve the metabolism of ifosfamide to its active alkylating metabolites.
pentobarbital will reduce the extent or effect of sufentanil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.
pentobarbital will reduce the extent or effect of voriconazole by impacting hepatic enzyme CYP2C9/ten metabolism. Small/Significance Unidentified.
pentobarbital will decrease the level or effect of vincristine liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Mysterious.
pentobarbital will lower the level or effect of lapatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will decrease the level or effect of mifepristone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers have not been examined, coadministration not advisable by manufacturer
pentobarbital will minimize the extent read more or effect of paclitaxel protein certain by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Not known.
pentobarbital decreases amounts of ponatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Prevent Until the coadministration outweighs the probable possibility of ponatinib underexposure; watch for signs of decreased efficacy.